Recent evidence suggests that small non-coding RNAs such as microRNA (miRNA) encapsulated in exosomes represent an important mechanism of communication between the cells. Exosomal miRNAs...
Read More »Recovery of serum exosomal microRNAs from FTA Elute cards for biomarker discovery and diagnostics
The preservation of nucleic acids from clinical samples is critical to facilitate accurate molecular diagnosis. The use of a paper matrix, Flinders Technology Associates (FTA) Elute cards, to archive DNA and viral RNA is well-documented. However, the feasibility of FTA ...
Read More »Exosome uptake by host cells is most promising for tailored exosomes as drug transporter
Exosomes (Exo), powerful intercellular communicators, are recovered in all body fluids, suggesting suitability for diagnosis and prognosis. Easy in vitro manipulation recommends Exo as drug vehicles. Aiming to consolidate diagnostic and therapeutic potential of Exo, researchers from the University Hospital of ...
Read More »MicroRNA Profiling of Exosomes
Exosomes are nano-sized membrane-bound vesicles released by a range of different cell types. Exosomes have been shown to specifically package certain membrane and cytosolic proteins and nucleic acids. Furthermore, it has been shown that their contents can be transferred to ...
Read More »Identifying Urinary and Serum Exosome Biomarkers for Radiation Exposure
Early and accurate assessment of radiation injury by radiation-responsive biomarkers is critical for triage and early intervention. Biofluids such as urine and serum are convenient for such analysis. Recent research has also suggested that exosomes are a reliable source of ...
Read More »Clinical relevance of circulating cell-free microRNAs in ovarian cancer
Ovarian cancer is the leading cause of death among gynecologic malignancies. Since ovarian cancer develops asymptomatically, it is often diagnosed at an advanced and incurable stage. Despite many years of research, there is still a lack of reliable diagnostic markers ...
Read More »Exosomal miRNAs as biomarkers of recurrent lung cancer
Prognosis of lung cancer still remains grim largely due to recurrence and aggressive metastasis of the disease. In this study, researchers from the University of Louisville examined the potential of exosomal miRNAs as biomarkers of recurrent lung cancer. Initially, in ...
Read More »Evaluation of optimal extracellular vesicle small RNA isolation for serum and urine samples
Circulatory microRNAs contained within extracellular vesicles (EVs) in biological fluids have developed great interest, due to their potential as non-invasive biomarkers. A variety of methods have been used to isolate EVs and their RNA content. Endogenous controls used for normalisation ...
Read More »Norgen Biotek Launches Novel Exosome Isolation and Exosomal microRNA Purification Kits
THOROLD, ON, Nov 2, 2015 /PRNewswire/ – Norgen Biotek, an innovative privately held Canadian biotechnology company focusing on advancing powerful tools for nucleic acids (NA) and protein purification, today announced the launch of novel kits for the fast and simple ...
Read More »Norgen Biotek Corp Launches over 15 Novel Kits for the Isolation of High-Quality Circulating Nucleic Acids from Blood, Plasma, Serum and Urine
THOROLD, ON, Sept. 28, 2015 /CNW/ – Norgen Biotek Corp., an innovative privately held Canadian biotechnology company focusing primarily on advancing powerful tools for nucleic acids (NA) and protein purification, today announced the launch of over 15 novel kits for ...
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