Tag Archives: Metastasis

Extracellular Vesicle Docking at the Cellular Port

exosomes

Extracellular vesicles (EVs), lipid bilayer-enclosed structures that contain a variety of biological molecules shed by cells, are increasingly becoming appreciated as a major form of cell-to-cell communication. Indeed, EVs have been shown to play important roles in several physiological processes, ...

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Exosome-Mediated Metastasis

exosome rna

Exosomes are extracellular signalosomes that facilitate eukaryotic intercellular communication under a wide range of normal physiological contexts. In malignancies, this regulatory circuit is co-opted to promote cancer cell survival and outgrowth. Tumour-derived exosomes (TDEs) carry a pro-EMT (epithelial-mesenchymal transition) programme ...

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Exosomes – integral component to the dynamic and reciprocal cross-talk between tumour cells and the metastatic niche

exosome rna

The development of life-threatening cancer metastases at distant organs requires disseminated tumour cells’ adaptation to, and co-evolution with, the drastically different microenvironments of metastatic sites. Cancer cells of common origin manifest distinct gene expression patterns after metastasizing to different organs. ...

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Exosomes Play Role in Bladder Cancer Metastasis

exosome rna

Researchers at Loyola University in Chicago have shown that exsomes isolated from invasive bladder cancer cell-conditioned media, or from patient urine or bladder barbotage samples, play a role in epithelial-to-mesenchymal transition (EMT), which is a biological process in which epithelial ...

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