Exosome-mediated transfer of regulatory RNAs is a key feature that enables cancer cells to shape a tumor-promoting environment. Cancers growing in the bone can use this communication modality to...
Read More »Towards rationally designed biomanufacturing of therapeutic extracellular vesicles
Extracellular vesicles (EVs), including exosomes, microvesicles, and others, have emerged as potential therapeutics for a variety of applications. Pre-clinical reports of EV efficacy in treatment of non-healing wounds, myocardial infarction, osteoarthritis, traumatic...
Read More »The microRNA regulatory landscape of MSC-derived exosomes
Mesenchymal stem cell (MSC)-derived exosomes mediate tissue regeneration in a variety of diseases including ischemic heart injury, liver fibrosis, and...
Read More »The role of stem cell derived exosomes in tumor biology
Exosomes are nano-scale messengers loaded with bio-molecular cargo of RNA, DNA, and Proteins. As a master regulator of cellular signalling, stem cell (both normal, and cancer stem cells) secreted exosome orchestrate various autocrine and paracrine functions which alter tumor micro-environment, ...
Read More »Role of stem cell-derived exosomes in cancer
Exosomes are small, extracellular membrane- enclosed vesicles that contain a variety of molecules, including proteins, DNA, mRNA and non-coding RNA; these vesicles have been defined as new tools for intercellular communication between cells. Numerous types of cells, including stem cells, ...
Read More »Exosomes as potential alternatives to stem cell therapy
The stem cell-based therapies for intervertebral disc degeneration have been widely studied. However, the mechanisms of mesenchymal stem cells interacting with intervertebral disc cells, such as nucleus pulposus cells (NPCs), remain unknown. Exosomes as a vital paracrine mechanism in cell-cell ...
Read More »Researchers use exosome mimetics for differentiation of therapeutic insulin-producing cells
The current diabetes mellitus pandemic constitutes an important global health problem. Reductions in the mass and function of β-cells contribute to most of the pathophysiology underlying diabetes. Thus, physiological control of blood glucose levels can be adequately restored by replacing ...
Read More »Mesenchymal stem cell exosomes offer hope in healing chronic wounds
from News-Medical.net Chronic non-healing wounds, common in patients with diabetes and paraplegia, affect over 6.5 million people annually and cost an estimated $25 billion a year in treatment alone in the United States. Offering new hope, is a study led ...
Read More »Extracellular vesicles in lung microenvironment and pathogenesis
Increasing attention is being paid to the role of extracellular vesicles (EVs) in various lung diseases. EVs are released by a variety of cells, including respiratory cells and immune cells, and they encapsulate various molecules, such as proteins and microRNAs, ...
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