Exosomes—tiny particles that are produced by all types of cells and circulate in the bloodstream—could be the basis for a blood test to diagnose...
Read More »Peripheral blood exosomes pass blood-brain-barrier and induce glial cell activation
Exosomes are involved in intracellular communication and contain proteins, mRNAs, miRNAs, and signaling molecules. Exosomes were shown to act as neuroinflammatory mediators involved in neurodegenerative diseases including Alzheimer’s disease (AD), Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS). Brain aging has ...
Read More »Extracellular vesicles and the search for biomarkers of dementias
Increased life expectancy impacts directly on the number of older people worldwide with the associated increase in neurodegenerative diseases. Besides their social implications, the different forms of dementia, including Alzheimer's disease...
Read More »A sensitive detection assay based on signal amplification technology for Alzheimer’s disease’s early biomarker in exosome
Alzheimer’s disease (AD) considered as the third health “killer” has seriously threatened the health of the elderly. However, the modern diagnostic strategies of AD present several disadvantages: the low...
Read More »Can nanotechnology help diagnose Alzheimer’s?
Researchers hope that the the ultrasmall messengers called exosomes (pictrure), can be used as an early-stage biomarker for Alzheimer’s disease, enabling a diagnosis to be made before the typical...
Read More »An optimized method for enrichment of whole brain-derived extracellular vesicles reveals insight into Alzheimer’s disease
Alzheimer's disease (AD) is the major cause of dementia that has increased dramatically in prevalence over the past several decades. Yet many questions still surround the etiology of AD. Recently, extracellular vesicles (EVs) that transport protein...
Read More »NanoSomiX, Inc. announces issuance of first US exosome patent
NanoSomiX, Inc. today announced that the United States Patent and Trademark Office (USPTO) has issued the company's first patent covering its groundbreaking proprietary exosome isolation and biomarker detection technology. U.S. Patent No...
Read More »How a small molecule halts exosome’s spread of a toxic protein
Alzheimer’s disease destroys brain cells in part by promoting the formation of insoluble clumps that contain a protein called tau. Not only are these...
Read More »Cell-to-cell communication by microglia related extracellular vesicles
Extracellular vesicles, including exosomes and microvesicles, are small, nano-to-micrometer vesicles that are released from cells. While initially observed in immune cells and reticulocytes as vesicles meant to remove archaic proteins, now they have been observed in almost all cell types ...
Read More »Exosomal Biomarkers In Down Syndrome And Alzheimer’s Disease
Every person with Down syndrome (DS) has the characteristic features of Alzheimer’s disease (AD) neuropathology in their brain by the age of forty, and most go on to develop AD dementia. Since people with DS show highly variable levels of ...
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