The ability of secreted extracellular vesicles (EVs) to target and transfer their cargo from donor to acceptor cells to trigger phenotypic changes in the latter has generated immense interest in the biological and commercial sectors. EVs are critical mediators of intercellular communication and regulate pleiotropic biological processes in target cells through horizontal transfer of specifically loaded protein, DNA, lipid, and RNA species. Importantly, EV cargo composition varies depending on cell type and cell environment stress. Not surprisingly, EVs have immense therapeutic potential and their cargos are receiving much attention as potential biomarkers for disease diagnosis and prognosis. EVs are present in most body fluids and as such are attractive non‐invasive candidates for disease diagnostics as well as longitudinal therapeutic response metrics of diseases such as cancer, heart disease, and neurodegeneration, in addition to rejection metrics for renal allografts.
Proetomics – special issue on extracellular vesicles and exosomes
Simpson RJ, Greening DW. (2019) Part II: Special Issue on Extracellular Vesicles and Exosomes. Proteomics 19(8):e1900121. [article]