Postdoc position available – the role of extracellular vesicles in venous thromboembolis

The position

The Faculty of Health Sciences has a Postdoctoral position available. The position is attached to the Department of Clinical Medicine, K.G. Jebsen – Thrombosis Research and Expertise Center (TREC) and the project “The pathogenic roles of extracellular vesicles and the complement system in venous thromboembolism.”

About the project

VTE has been long considered a disease that is caused by blood hypercoagulability. However, accumulating evidence speak for major involvement of inflammatory processes such as production and release of procoagulant extracellular vesicles (EVs) by intravascular cells (endothelial cells, monocytes, neutrophils and platelets) and activation of the complement system. Such processes occur at the site of thrombus formation in the venous valve pocket. This project therefore aims to study the characteristics and procoagulant activities of EVs and the complement system in the context of VTE pathogenesis. The successful candidate will study the role of EVs, their proteome, procoagulant activity and crosstalk with the complement system. As EVs are implicated in disease mechanisms and are readily accessible in all body fluids, they are attractive targets for future development of diagnostic tools and novel therapeutic regimens interfering with the activities of EVs.

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