Henry Ford physician receives NIH grant for first-of-its-kind study of keloid exosomes

Lamont R. Jones, M.D., MBA, vice chair for the Department of Otolaryngology – Head and Neck Surgery at Henry Ford Health System, received a five-year, $895,814 grant from the National Institutes of Health to fund a research project titled, “Characterization of Keloid Specific Exosomes and Determination of Exosomal Critical Signaling Pathways in the Keloid Microenvironment.”

Each year, more than 11 million people in the world suffer from keloids, resulting in more than 425,000 associated clinic visits in the United States. Keloids are benign fibroproliferative tumors, which can result in excessive growths of scar-like tissue on the skin. They develop over injuries, such as trauma, burns, surgery, piercings, tattoos, acne and ingrown hair in at-risk people.

Keloids often cause pain, severe itching, emotional distress and loss of function. They are more common in patients with darker skin, including those of African, Hispanic, Middle Eastern and Asian descent. However, Caucasians are also affected. Clinical outcomes for the treatment of keloids are disappointing with high recurrence rates, mainly due to the lack of knowledge regarding the mechanisms of keloid formation.

There are currently no FDA-approved therapies for keloids.

To date, much of the research into keloid development has focused primarily on genetic mechanisms. This approach has yielded few tangible results, with large gaps in the understanding of keloid pathogenesis.

“Currently, there are no published studies on keloid exosomes,” Dr. Jones said. “Preliminary data from our research shows the potential contribution of exosomes in keloid development. We believe this data could eventually open the door to novel exosome-based keloid therapies.”

Exosomes are small vesicles that facilitate important cellular functions. They transport bioactive molecules between cells, which is an important part of cell-to-cell communication. Preliminary data from the research has identified RAB27 proteins as being differentially hypomethylated in keloid versus normal skin. The data has also identified keloid-specific exosomes. Currently, there are no published reports regarding the contribution of RAB27 methylation on exosome production and function.

Source – Eurekalert

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