Extracellular vesicles (EVs), which are generated by almost all living cells, are now considered to be an important system of cell–cell communication. A large volume of data has been published on EVs in different fields of biology and medicine, from immunology to marine biology. These data are discussed at large international meetings that gather thousands of researchers.However, there is still a need for more-focused meetings at which the importance and reliability of the data should be evaluated by a narrow circle of experts. Here, we propose to organize a small conference that will focus on one of the most important aspects of EVs, their role in infectious human diseases. The aim of the proposed conference is to improve our understanding of the mechanisms of this involvement and to evaluate EVs as potential therapeutic targets.
Key Sessions to include:
- Extracellular vesicles generated by human cells: a diverse population of vesicles formed by diverse biogenesis and having diverse composition.
- Extracellular vesicles as mediators of communications between human cells in vitro and in vivo: proved cases vs. unproved hypotheses.
- Extracellular vesicles in retroviral pathogenesis: human retroviruses as close relatives of extracellular vesicles.
- Extracellular vesicles as carriers of viral proteins and infectious viruses.
- Extracellular vesicles in bacterial pathogenesis: effects of bacterial vesicles on human tissues.
- Extracellular vesicles in complicated pregnancies: EVs as mediators of disruption of mother-to-child dialogue in infections.
- Extracellular vesicles as vehicles carrying RNA and soluble factors between cells.
- Isolation and characterization of different vesicles generated by human cells in vivo and in vitro: Is this mission possible?