Exosomes are small extracellular vesicles that mediate intercellular signaling in the brain without requiring direct contact between cells. Although exosomes have been shown to play a role in neurological diseases and in response to nerve trauma, a role for exosome-mediated signaling in brain development and function has not yet been demonstrated. Here the authors review data building a case for exosome function in the brain.
- Sharma P, Schiapparelli L, Cline HT. (2013) Exosomes function in cell-cell communication during brain circuit development. Curr Opin Neurobiol [Epub ahead of print]. [abstract]