Metastasis, a critical phase of tumor progression, remains a primary challenge in treating cancer and a major cause of cancer mortality. Cell-cell communication via extracellular vesicles (exosomes and microvesicles) between primary tumor cells and the microenvironment of distant organs is crucial for pre-metastatic niche (PMN) formation and metastasis. Weill Cornell Medicine researchers review work on the contribution of exosome cargo to cancer progression, the role of exosomes in PMN establishment, and the function of exosomes in organotropic metastasis. They also describe the clinical utility of exosomes.
Wortzel I, Dror S, Kenific CM, Lyden D. (2019) Exosome-Mediated Metastasis: Communication from a Distance. Dev Cell 49(3):347-360. [article]
Tagged with: bone-marrow-derived cell cancer exosome Extracellular matrix extracellular vesicle immune cell integrins intercellular communication Metastasis microvesicle Pre-metastatic niche vascular leakiness