Extracellular vesicles (EVs), derived from cell membranes, demonstrate the potential to be excellent therapeutics and drug carriers. Although EVs are promising, the process to develop high-quality...
Read More »Exosomes and Their Role in Cancer Progression
Exosomes are a subset of extracellular vesicles and their size is approximately 100 nm in diameter. They are surrounded by a lipid bilayer membrane and secreted from almost all of cells. Exosomes are generated within the endocytic system as ILV ...
Read More »Modulating the Non-Hodgkin Lymphoma microenvironment with exosomes
There has been a shift in the paradigm of Non-Hodgkin lymphomas, changing from the classical genetic aberration-based model to a more complex and dynamic model involving tumor microenvironment interactions. In this instance, exosomes have...
Read More »Extracellular Vesicles As Nanomedicine – Hopes And Hurdles In Clinical Translation
The clinical development of cell therapies is revealing that extracellular vesicles (EVs) may become very instrumental as subcellular therapeutic adjuncts in human medicine. EVs are released by various types of cells, grown in culture, such as...
Read More »Extracellular vesicles – a novel source of biomarkers in liquid biopsies for monitoring cancer progression and drug resistance
Cancer-derived extracellular vesicles (EVs) have been detected in the bloodstream and other biofluids of cancer patients. They carry various tumor-derived molecules such as mutated DNA and RNA fragments...
Read More »Advanced liquid biopsy technologies for circulating biomarker detection
Liquid biopsy is a new diagnostic concept that provides important information for monitoring and identifying tumor genomes in body fluid samples...
Read More »Promise of extracellular vesicles for diagnosis and treatment of epilepsy
Extracellular vesicles (EVs) released from cells play vital roles in intercellular communication. Moreover, EVs released from stem cells have therapeutic properties. Researchers from Texas A&M University College of Medicine discuss the potential of brain...
Read More »Bacterial extracellular vesicles – a new way to decipher host-microbiota communications in inflammatory dermatoses
Bacterial Extracellular Vesicles (EVs) are bilayered lipid membrane structures, bearing integral proteins and able to carry diverse cargo outside the cell to distant sites. In microorganisms, EVs carry several...
Read More »The pre-analytical phase of the liquid biopsy
The term ‘liquid biopsy’, introduced in 2013 in reference to the analysis of circulating tumour cells (CTCs) in cancer patients, was extended to cell-free nucleic acids (cfNAs) circulating in blood and other body fluids. CTCs and cfNAs are now considered ...
Read More »Exosomal MiRNAs in Pediatric Cancers
MicroRNAs (miRNAs) have generated great attention in oncology as they play a fundamental role in the regulation of gene expression and their aberrant expression is present in almost all types of tumors including pediatric ones. The discovery that miRNAs can ...
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