Recently, exosomes have been emerged as promising drug delivery carriers, while certain tissues are intrinsically resistant to exosomes. Therapeutically improving the drug delivery efficiency in these...
Read More »TEM ExosomeAnalyzer – a computer-assisted software tool for quantitative evaluation of extracellular vesicles in transmission electron microscopy images
Extracellular vesicles (EVs) function as important conveyers of information between cells and thus can be exploited as drug delivery systems or disease biomarkers. Transmission electron microscopy (TEM)...
Read More »A dual signal amplification method for exosome detection based on DNA dendrimer self-assembly
An increasing number of studies have found that circulating exosomes play a vital role in the occurrence and metastasis of cancer. Therefore, a direct, sensitive and specific method for detection of tumor exosomes will contribute to the diagnosis and prognosis ...
Read More »Stiffness measurement of nanosized liposomes using solid-state nanopore sensor with automated recapturing platform
Researchers from Southern Methodist University describes a method to gauge the stiffness of nanosized liposomes – a nanoscale vesicle – using a custom-made recapture platform coupled to a...
Read More »Direct isolation and characterization of circulating exosomes from biological samples using magnetic nanowires
Tumor-derived exosomes are gaining attention as important factors that facilitate communication between neighboring cells and manipulate cellular processes associated with cancer development or...
Read More »Highly sensitive detection of exosomes by 3D plasmonic photonic crystal biosensor
Researchers from City University of Hong Kong have developed and fabricated two-dimensional (2D), quasi-three-dimensional (3D), and 3D plasmonic photonic crystal (PPC) nanostructures with point-defect cavities using direct and reversal nanoimprint lithography. As a result of the hybrid coupling of localized ...
Read More »Tangential flow filtration for highly efficient concentration of extracellular vesicles from large volumes of fluid
Concentration of extracellular vesicles (EVs) from biological fluids in a scalable and reproducible manner represents a major challenge. Mayo Clinic researchers report the use of tangential flow filtration...
Read More »Large-scale, cross-flow based isolation of highly pure and endocytosis-competent extracellular vesicles
Isolation of extracellular vesicles (EVs) from cell culture supernatant or plasma can be accomplished in a variety of ways. Common measures to quantify relative success are: concentration of the EVs, purity from non-EVs associated protein, size homogeneity and functionality of ...
Read More »Cadmium-free quantum dots as fluorescent labels for exosomes
Quantum dots are attractive alternatives to organic fluorophores for the purposes of fluorescent labeling and the detection of biomarkers. They can also be made to specifically target a protein of interest by conjugating biomolecules, such as antibodies. However, the majority ...
Read More »Microfluidic on-demand engineering of exosomes towards cancer immunotherapy
Extracellular Vesicles (EVs), particularly exosomes (30-150 nm), are an emerging delivery system in mediating cellular communications, which have been observed for priming immune responses by presenting parent cell signaling proteins or tumor antigens...
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