Tag Archives: Metastasis

Unshielding Exosomal RNA Unleashes Tumor Growth And Metastasis

Reciprocal interactions between tumor cells and their microenvironment drive cancer progression and therapy resistance. Researchers demonstrate that dynamic feedback between tumor and stroma subverts normal inflammatory responses by triggering the release of exosomes containing unshielded RNAs that activate pattern recognition receptors, ...

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Role of stem cell-derived exosomes in cancer

exosomes

Exosomes are small, extracellular membrane- enclosed vesicles that contain a variety of molecules, including proteins, DNA, mRNA and non-coding RNA; these vesicles have been defined as new tools for intercellular communication between cells. Numerous types of cells, including stem cells, ...

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Extracellular Vesicle Docking at the Cellular Port

exosomes

Extracellular vesicles (EVs), lipid bilayer-enclosed structures that contain a variety of biological molecules shed by cells, are increasingly becoming appreciated as a major form of cell-to-cell communication. Indeed, EVs have been shown to play important roles in several physiological processes, ...

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Exosome-Mediated Metastasis

exosome rna

Exosomes are extracellular signalosomes that facilitate eukaryotic intercellular communication under a wide range of normal physiological contexts. In malignancies, this regulatory circuit is co-opted to promote cancer cell survival and outgrowth. Tumour-derived exosomes (TDEs) carry a pro-EMT (epithelial-mesenchymal transition) programme ...

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