Role of stem cell-derived exosomes in cancer

Exosomes are small, extracellular membrane- enclosed vesicles that contain a variety of molecules, including proteins, DNA, mRNA and non-coding RNA; these vesicles have been defined as new tools for intercellular communication between cells. Numerous types of cells, including stem cells, secrete exosomes into the extracellular environment, and are significant communicators in the tumor microenvironment. Stem cells are a unique cell population defined by their ability to indefinitely self-renew, differentiate into a variety of cell lines, and form clonal cell populations. Stem cells also secrete large amounts of exosomes, which have demonstrated great potential in a variety of diseases. Increasing evidence has revealed that the mechanism of interaction between stem cells and human tumor cells involves the exchange of biological material through exosomes. Researchers from Nanjing University highlight the latest developments in the role of stem cell-derived exosomes in cancer.

Proposed model for therapeutic application of exosomes

exosomes

MSC- and CSC-derived exosomes may be used to mediate anti-proliferative or pro-apoptotic effects of anti-cancer therapy. These exosomes may also serve as effective drug delivery vehicles. MSCs, mesenchymal stroma/stem cells; CSCs, cancer stem cells; miRNA, microRNA.

Wu J, Qu Z, Fei ZW, Wu JH, Jiang CP. (2017) Role of stem cell-derived exosomes in cancer. Oncol Lett 13(5):2855-2866. [article]

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