ReNeuron Wins $3 Million UK Grant to Advance Its Exosome Nanomedicine Platform

exosome rnaOn January 11, 2016, the ReNeuron Group plc (AIM: RENE), a leading UK-based stem cell therapy development company, announced that it has been awarded a £2.1 million (just over $3 million) grant from Innovate UK to further advance the company’s emerging exosome nanomedicine platform ( The grant, entitled “Stem Cell-Derived Exosomes for Regenerative Medicine,” has been awarded under Innovate UK’s Developing Regenerative Medicine & Cell Therapies” grant scheme and will fund a collaborative program of work to be undertaken by ReNeuron, as lead participant, and its collaborators on the grant, namely, the Cell Therapy Catapult and the Department of Biochemical Engineering at University College London. The grant will fund key pre-clinical development work packages relating to ReNeuron’s exosome nanomedicine platform. These include the development of robust manufacturing systems utilizing scalable bioreactors and purification technologies that will enable the production of ReNeuron’s exosomes at a commercial scale. The work program also includes product characterization and potency assay development, as well as pre-clinical efficacy and toxicity testing of the selected exosome nanomedicine candidate. ReNeuron is exploiting the therapeutic potential of exosomes derived from its proprietary stem cell lines. The company is also exploring the potential of its exosomes as a delivery system for gene therapy treatments. Exosomes are lipid-based nanoparticles secreted from all cells and which are believed to play a key role in the transfer of beneficial proteins and particularly non-coding RNAs from one cell to another. ReNeuron researchers have identified a novel mechanism by which exosomes from its clinical-grade neural stem cell line (CTX stem cells) may inhibit the growth and migration of cancer cells in pre-clinical models of the disease. ReNeuron has filed multiple patent applications covering the composition, manufacture, and therapeutic use of its exosome nanomedicine platform and the company is continuing to investigate the mechanism of action and utility of its exosome nanomedicine platform in a range of potential cancer indications.

Commenting on the grant award, Olav Hellebø, CEO of ReNeuron, said: “ReNeuron is a global leader in the exciting new field of exosome therapeutics and we are therefore delighted to have won this prestigious grant from Innovate UK. The grant application process was highly competitive and subjected our exosome nanomedicine program to expert technical peer review. As a result, the award of the grant represents a strong endorsement of the potential of this emerging advanced therapy platform and will enable us to rapidly progress its development towards initial clinical application.”


Innovate UK works with people, companies and partner organisations to find and drive the science and technology innovations that will grow the UK economy – delivering productivity, new jobs and exports. The aim at Innovate UK – the government’s innovation agency – is to keep the UK globally competitive in the race for future prosperity. For further information, please visit


ReNeuron is a leading, clinical-stage cell therapy development company. Based in the UK, its primary objective is the development of novel cell-based therapies targeting areas of significant unmet or poorly met medical need. ReNeuron has used its unique stem cell technologies to develop cell-based therapies for significant disease conditions where the cells can be readily administered “off-the-shelf” to any eligible patient without the need for additional immunosuppressive drug treatments. The company has therapeutic candidates in clinical development for motor disability as a result of stroke, for critical limb ischemia, and for the blindness-causing disease, retinitis pigmentosa.

ReNeuron is also advancing its proprietary exosome technology platform as a potential new nanomedicine targeting cancer and as a potential delivery system for gene therapy treatments.

ReNeuron’s shares are traded on the London AIM market under the symbol RENE.L. Further information on ReNeuron and its products can be found at

Source – Reneuron

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