The Hamner-University of North Carolina Institute for Drug Safety Sciences (IDSS) is dedicated to understanding, predicting, and preventing adverse reactions to drugs. The IDSS is located in Research Triangle Park, NC and directed by Paul Watkins, M.D., one of the leading experts in clinical drug-induced adverse reactions. This partnership between The Hamner and The University of North Carolina at Chapel Hill, one of the world’s premier biomedical research universities, has fostered alliances between the pharmaceutical industry, academia, and the FDA. Researchers within the IDSS utilize cutting-edge technologies to improve the understanding of toxicity mechanisms and mitigate the risk associated with adverse drug reactions.
Outstanding and motivated candidates are sought for a position exploring the utility of hepatocyte-derived exosomes to improve the prediction and understanding of drug-induced liver injury (DILI). The goal of this effort is to identify more sensitive, specific and mechanistic biomarkers for DILI in order to help to improve patient safety and drug development. This project is a collaboration between the IDSS (Dr. Paul Watkins and Dr. Merrie Mosedale) and Janssen Pharmaceuticals. Responsibilities will include design and implementation of in vitro and in vivo studies to understand the influence of drug exposure and toxicity on the content and number of exosomes released from the liver. Data collection will utilize cutting-edge imaging and omics based approaches as well as molecular biology techniques. The successful candidate will have interactions with the investigative toxicology team at Janssen, as well as world class toxicologists, systems biologists, and cellular engineering experts at The Hamner Institutes. The initial appointment will be for one year, with the possibility of extension.
Qualifications and Experience
Ideal candidates will have a Ph.D. in biology, toxicology or pharmacology with 0-3 years of postdoctoral training. They will have hands on experience conducting cell culture and in vivo rodent studies and be proficient in molecular biology techniques including protein and gene expression analysis. Extensive prior experience with transcriptomics and proteomics analysis is desirable but not essential.
Qualified candidates need to submit their resume and a postdoctoral application which can be found at http://www.thehamner.org/careers/application-forms/ by email to firstname.lastname@example.org or by fax to 919-558-1430.
Please refer to the “Postdoctoral Position in Drug Safety – Biomarker Discovery” position.
“Equal Opportunity/Affirmative Action Employer – minority/female/disability/veteran”