Post-doc position available – exosomes for delivery of CRISPR/Cas9

Location:

Gothenburg, Västra Götaland, Sweden

Job reference: R-023430
Posted date: Mar. 07, 2018

Postdoctoral Long Title:

Extracellular vesicles as a delivery vehicle for CRISPR/Cas9 for therapeutic gene editing.

We’re currently looking for talented scientists to join our innovative academic-style Postdoc. From our centre in Choose or Enter a Location, you’ll be in a global pharmaceutical environment, contributing to live projects right from the start. You’ll take part in a comprehensive training programme, including a focus on drug discovery and development, given access to our existing Postdoctoral research, and encouraged to pursue your own independent research in cutting edge laboratories. It’s a newly expanding programme spanning a range of therapeutic areas across a wide range of disciplines.

What’s more, you’ll have the support of a leading academic advisor, who’ll provide you with the guidance and knowledge you need to develop your career. This is an exciting area that hasn’t been explored to its full potential, making this an opportunity to make a real difference to the future of medical science.

About AstraZeneca             

AstraZeneca is a global, innovation-driven biopharmaceutical business that focuses on the discovery, development and commercialisation of prescription medicines for some of the world’s most serious diseases. But we’re more than one of the world’s leading pharmaceutical companies. At AstraZeneca, we’re proud to have a unique workplace culture that inspires innovation and collaboration. Here, employees are empowered to express diverse perspectives – and are made to feel valued, energised and rewarded for their ideas and creativity.

Our Discovery Sciences team operates from truly state-of-the-art centres spanning the UK, US and Sweden. You’ll work with some of the most knowledgeable technology experts in the industry, all collaborating on high-profile drug discovery projects. Cancer is one of the greatest challenges facing medical science today. In collaboration with our Oncology Team, you’ll push the boundaries of science every day to overcome that challenge. We’ve been at the centre of some of the biggest breakthroughs in oncology. In lung cancer, for example, we‘ve brought together complementary expertise to aid discovery and accelerate development in new medicines through a variety of partnerships and initiatives. We’re also early adopters of new technologies to support innovation, including CRISPR, genome editing techniques, transcriptomics and a next-generation sequencing platform for companion diagnostics in oncology. But we’re not stopping there. With a world-class pipeline and some of the best experts in the industry, we’re in a great position to develop even more innovative therapeutic approaches and the opportunities to develop your expertise here are limitless.

This is a unique opportunity to be part of a larger global, interdisciplinary team of highly skilled and motivated postdoctoral scientists, dedicated to investigating the therapeutic potential of engineered exosomes as tissue-specific delivery vehicles. Recent studies have demonstrated that exosomes can be used as a delivery system for therapeutic agents such as siRNA and small molecules directly to specific diseased tissues to elicit favorable biological responses in vitro and in vivo. This new post doc position seek to build on these reports by using cutting-edge cell and protein engineering methodologies to further develop this novel platform for delivery of RNA therapeutic drugs.

Molecular mechanism of intracellular trafficking of RNA into exosomes

The research will be focused on intracellular trafficking of RNA and biological mechanisms of how RNA cargo is integrated into newly formed exosomes during biogenesis. You will explore molecular evolution of RNA to identify sequence elements responsible for targeting of cytosolic RNA into exosomes. Once such RNA sequences have been identified you will further investigate the proteins involved in sorting and develop hypothesis for the biological mechanism around exosome formation.

Education and Experience Required:

Essential:

  • A PhD in biological sciences with a strong cell biology or biochemical focus.
  • Excellent expertise with molecular biology techniques, gene manipulation, protein engineering and mammalian cell culture.
  • Excellent organizational, communication and interpersonal skills, combined with the ability to work collaboratively across boundaries and problem solve in the absence of complete information.
  • A strong scientific track record, as evidenced by published papers in high quality peer-reviewed journals.

Desirable:

  • working experience of isolation, characterization and manipulation of exosomes.
  • Practical experience of selection, panning and directed evolution techniques.
  • Postdoctoral experience
  • understanding of drug delivery
  • Experience of cell imaging, confocal microscopy, FACS and RT-PCR.
  • Working knowledge of RNA therapeutics and gene editing technologies.
  • Expertise with RNA engineering.

This is a 3 year programme.  2 years will be a Fixed Term Contract, with a 1 year extension which will be merit based.  The role will be based at Gothenburg with a competitive salary on offer

To apply for this position, please click the apply link below.

Advert opening date – 5th March 2018

Advert closing date – 13th May 2018

AstraZeneca welcomes applications from all sections of the community.

AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law.

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