In recent years the knowledge about the control of tumor microenvironment has increased and emerged as an important player in tumorigenesis. The role of normal stromal cells in the tumor initiation and progression has brought our vision in to the forefront of cell-to-cell communication. In this review, the authors focus on the mechanism of communication between stromal and tumor cells, which is based on the exchange of extracellular vesicles. They describe several, ever-growing, pieces of evidence that extracellular vesicles transfer messages through their miRNA, lipid, protein and nucleic acid contents. A better understanding of this sophisticated method of communication between normal cancer cells may lead to developing novel approaches for personalized diagnostics and therapeutics.