Exosome-coated Metal-Organic Framework Nanoparticles – An Efficient Drug Delivery Platform

Researchers at Ludwig-Maximilians-University report on the synergistic combination of metalorganic framework (MOF) nanoparticles and exosomes for drug delivery, exploiting the advantageous properties of each compound. They successfully coat drug-loaded MOF nanoparticles with exosomes via lipid fusion and thereby facilitate drug loading of exosomes with unprecedented efficiency. The resulting exosomecoated nanoparticles show no premature leakage, yet efficient release of their cargo in cells. When loaded with a chemotherapeutic agent as biologically active cargo, cell viability is decreased with high efficacy. A novel mechanism for the efficient release is proposed based on the decomposition of the MOF nanocarrier allowing for drug escape from the endosome in combination with possible endogenous exosomal release mechanisms. The chemical tunability of the MOF core combined with the cell-derived – potentially even autologous – exosome shell provides an innovative drug delivery platform for biomedical applications

exosomes

Schematic illustration of the synthesis of the exosome coated MOF and the subsequent cell uptake and proposed release mechanism of the cargo

Illes B, Hirschle P, Barnert S, Cauda V, Wuttke S, and Engelke H. (2017) Exosome-coated Metal-Organic Framework Nanoparticles: An Efficient Drug Delivery Platform. Chem of Mat [Epub ahead of print]. [abstract]

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