Elucidating the role of exosomes in bronchial asthma

Ankur Kulshreshtha*, Tanveer Ahmad, Anurag Agrawal, Balaram Ghosh

*Corresponding author: Ankur Kulshreshtha
Molecular Immunogenetics Laboratory, Institute of Genomics and Integrative Biology, Delhi, India

F1000Posters 2012, 3: 426 (poster) [English]

Presented at:
1st Annual Meeting of the International Society for Extracellular Vesicles 2012, 18 – 21 Apr 2012, 15

Affiliated Society:
International Society for Extracellular Vesicles

Background / Purpose:
There is emerging understanding about various cellular interactions in the initiation and progression of asthma, but the process of communication among cells is not known.Exosomes are being increasingly implicated as an important communication tool amongst different cell types, so it would be interesting to elucidate the role of exosome-mediated crosstalk in the progression of asthma.
Main conclusion:
Epithelial-cell derived exosomes could play an important role in orchestrating immune regulation in lungs by interacting with cells of the immune system and modulating their functions.
Next steps:

It would be interesting to find out the individual components of exosomes responsible for their mode of action.

No relevant competing interests disclosed.
Council for Scientific and Industrial Research, NWP0033
Council for Scientific and Industrial Research , MLP5501

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