A research team at the National Institute on Aging has been a pioneer in harvesting extracellular vesicles (EVs) enriched for neuronal origin from peripheral blood and using them as a biomarker discovery platform for neurological disorders. This methodology has demonstrated excellent diagnostic ...

Early detection of cancer plays a crucial role in disease prognosis. It requires the recognition and quantification of low amounts of specific molecular biomarkers, either free or transported inside nanovesicles, through the development of novel sensitive diagnostic technologies. In this ...

Yusuke Yoshioka – National Cancer Center Research Institute, Tokyo Japan – In 1975, Georges Jean Franz Köhler and César Milstein developed a technology of monoclonal antibody production and won Nobel Prize in Physiology or Medicine in 1984. This technology simply ...

Exosomes (Exo), powerful intercellular communicators, are recovered in all body fluids, suggesting suitability for diagnosis and prognosis. Easy in vitro manipulation recommends Exo as drug vehicles. Aiming to consolidate diagnostic and therapeutic potential of Exo, researchers from the University Hospital of ...

The physiological role of miRNAs is widely understood to include fine-tuning the post-transcriptional regulation of a wide array of biological processes. Extensive studies have indicated that exosomal miRNAs in the bodily fluids of various organisms can be transferred between living ...

Wilna Oosthuyzen and Matthew Bailey, from the Centre for Cardiovascular Science, University of Edinburgh, introduce Nanoparticle Tracking Analysis (NPA), a new technique to quantify Human Urinary Exosomes. NPA has proven a faster and more precise method compared to the Western ...

To study the inhomogeneity within a cell population including exosomes properties such as exosome secretion rate of cells and surface markers carried by exosomes, we need to quantify and characterize those exosomes secreted by each individual cell. Researchers from the ...

Researchers at the Beijing Friendship Hospital used ExoQuick-TC™ Exosome Precipitation Solution to isolate exosomes from the serum of colon cancer patients and identify RNAs in the small vesicles. The shapes of exosomes were observed under a transmission electron microscope. Mass ...

Extracellular vesicles (EVs) derived from stem and progenitor cells may have therapeutic effects comparable to their parental cells and are considered promising agents for the treatment of a variety of diseases. To this end, strategies must be designed to successfully ...

Exosomes are both active in mediating intracellular communication and potentially present a potent cargo of disease biomarkers to an assay. The robust evaluation of exosomal markers could lead to a paradigm shift in clinical analysis and associated care. To date, ...